High Resolution Liquid NMR

Liquid NMR is a fundamental tool both in chemistry and biomedicine research. Its applications to chemistry range from structure elucidation of small molecules to studies of ligand-protein interactions. In biomedicine, the use of liquid NMR has expanded from the classical metabolic studies using enriched stable isotope tracers to the more recent NMR-based metabolomics of biofluids (urine, plasma, CSF).

Equipment:

Bruker Ascend 400 MHz NMR spectrometer

Bruker Avance 600 MHz NMR spectrometer

• Structure verification and elucidation
• Molecular mobility: determination of conformation in solution
• Determination of enantiomeric excess
• Kinetic and temperature studies of reaction mixtures
• Metabolomics of liquid samples (CSF, plasma, urine and tissue extracts)In vivo Metabolism using enriched stable isotope tracers