High Resolution Liquid NMR

Developed by: Centro Andaluz de Nanomedicina y Biotecnología BIONAND

Description

Liquid NMR is a fundamental tool both in chemistry and biomedicine research. Its applications to chemistry range from structure elucidation of small molecules to studies of ligand-protein interactions. In biomedicine, the use of liquid NMR has expanded from the classical metabolic studies using enriched stable isotope tracers to the more recent NMR-based metabolomics of biofluids (urine, plasma, CSF).


Equipment:

Bruker Ascend 400 MHz NMR spectrometer

Bruker Avance 600 MHz NMR spectrometer

Applications

  • Structure verification and elucidation
  • Molecular mobility: determination of conformation in solution
  • Determination of enantiomeric excess
  • Kinetic and temperature studies of reaction mixtures
  • Metabolomics of liquid samples (CSF, plasma, urine and tissue extracts)In vivo Metabolism using enriched stable isotope tracers

Mª Carmen Muñoz

mcmunoz@bionand.es

952 367 637