Aortic endoprosthesis for the treatment of aneurysms

Developed by: Instituto de Investigación Sanitaria Hospital La Paz


Description and essential characteristics

Aortic endoprosthesis that, by means of its innovative approach (the use of tissue engineering) and design, definitively treats and heals aortic aneurysms.

The endoprosthesis is formed by a tubular body designed for attachment in the abdominal aorta (the means of attachment are designed to ensure the position of this tubular body) and a bag that is attached to and wraps around the tubular body creating a compartment. The bag is designed to expand in the aneurysm sac and has a small orifice for the passage of a catheter through which a stem-cell-based treatment is introduced within the compartment. This causes the bag to expand like a balloon within the aneurysm sac excluded from circulation by the tubular body.

Once the cells have been inserted into the bag, the orifice is closed by the pressure exerted by the endoprosthesis on the artery. The bag thereby ensures the confinement of cells in its interior and prevents leakage.

The bag is made of a bioabsorbable material that is reabsorbed a few days after implantation, in such a way that the inserted content has time to stabilise within its interior.

This new endoprosthesis design, along with the regenerative and repairing action of the cells inserted in its interior, treats the aneurysm and also prevents the leakage of blood and cells in the space defined between the outer surface of the prosthesis and the inner wall of the aneurysm sac.

Competitive advantages

This new endoprosthesis reduces the diameter of the aneurysm sac, promoting active healing (treating the sac directly) and ensuring the confinement of cells until they have stabilised within the thrombosed sac. This new endoprosthesis design significantly reduces the majority of risks inherent in these types of interventions:

  • Repressurisation of the aneurysm
  • Embolisation
  • Blood and cell leakage in the space defined between the outer surface of the prosthesis and the inner wall of the aneurysm sac
  • Migration of the endoprosthesis

By definitively treating the disease, the device also avoids the need for subjecting the patient to permanent medical follow-up and additional surgery due to the disease not being completely cured.

Lastly, production costs for the new endoprosthesis would not represent any higher costs versus current device models, given the fact that this device is based on current designs and production.


Biologically treats abdominal aortic aneurysms.

Estado de protección

Spanish patent P201231638, granted in May 2015.

International patent application PCT/ES2013/070712.

Desired cooperation

Cooperation is sought with any Party interested in partnering, licensing or investing in the technology, whether it be an investor to fund the project, a partner interested in getting involved in any of the various phases until its placement on the market, a patent licensee, etc. The organisations potentially interested in this technology are those devoted to the manufacture, commercialisation and/or distribution of healthcare products, particularly medical devices; as well as hospitals, vascular surgery clinics, etc.

Innovation Support Unit

Foundation for Biomedical Research of La Paz University Hospital - FIBHULP-IdiPAZ

Edificio IdiPAZ, Planta Baja
Paseo de la Castellana, 261
28046 Madrid
Tfno: 91 207 12 34

email: innovacion(ELIMINAR)


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