Kit to predict the risk of infection after a heart attack or major surgery
Developed by: Instituto de Investigación Sanitaria Hospital La Paz
Description and essential characteristics
This kit predicts the risk of developing an infectious disease after a myocardial infarction or major surgery, thus enabling the design of personalised and prompt treatment for the patient. The kit is based on the detection and quantification of a specific biomarker in a biological sample isolated from the patient, and makes it possible to predict which patients are predisposed to infection, thus promoting simultaneously the prevention of septicaemia.
The technology is based on published research by this group showing that the presence of a specific substance (biomarker) in a biological sample is associated with a state of tolerance to infections (or a refractory state), and also on the relationship between the patient’s immunologic refractory state before and after surgery and the risk of developing an infectious disease after surgery.
This tool will allow doctors to initiate antibiotic treatment in those patients who are to undergo or have just undergone surgery and have a high risk of developing an infectious disease, thus simultaneously preventing the indiscriminate use of antibiotics in similar patients who have a low risk of developing an infectious disease.
This kit is also useful in determining the doses of antibiotics to be administered, if antibiotics are necessary.
This tool makes it possible to know in a non-invasive, fast, and simple manner whether or not the patient needs antibiotic treatment to prevent infection, thus promoting simultaneously the prevention of septicaemia. The kit offers an efficiency not achieved so far with kits currently available on the market
Septitest® from Molzym Molecular Diagnostics, SeptiFast® from Roche Pharmaceuticals and Plex-ID® from Abbott are able to identify dozens of bacteria, fungi and even antibiotic resistance plasmids, but none study the immunological status of the patient in order to predict the risk of infection. The key is in Immune Tolerance.
The kit is especially useful for patients who are to undergo surgery and have tolerance to infections, as depending on the test results it is possible to postpone surgery or establish preventive antibiotic therapy. In addition, in the case of a patient who has just undergone major surgery or suffered a heart attack, the kit will provide improved monitoring of the patient’s evolution.
Estado de protección
Spanish patent P201330768, applied for in May 2013.
International patent application PCT/ES2014/070434.