New therapeutic agents for treating inflammatory disorders
Developed by: Instituto de Investigación Sanitaria Hospital La Paz
Description and essential characteristics
A new generation of inhibitors of TNF-α production that are useful for the prevention and/or treatment of inflammatory diseases such as rheumatoid arthritis, osteoarthritis, Crohn's disease, ulcerative colitis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, ankylosing spondylitis, hidradenitis supurativa, dermatitis and any other inflammatory condition which evolves with high levels of TNF-α.
These compounds are able to inhibit the expression of TNF-α at the transcriptional level in human primary monocytes, which suggests that the mechanism could be related to the activity of a transcription factor and might also regulate the expression of additional cytokines. The effect seems to be independent of p38 MAPK or c-jun activation. Preliminary data suggest that NFkB activity could be affected.
In addition to TNF-α, these compounds also down-regulate the production of IL-1β and IL-
Because metabolic diseases are related to low-grade inflammation, the action of the compounds on human mature adipocytes generated in vitro from human mesenchimal stem cells has also been explored. The results show a dose-dependent downregulation of IL-6 and leptin production by human adipocytes stimulated with LPS.
In vivo studies in animal models previously treated with low doses of these compounds show significantly less TNF-α production when challenged with a potent proinflammatory stimulus such as LPS. This result indicates that the compounds have anti-inflammatory efficacy when administered in vivo.
Regarding safety, long-term treatment of mice with low doses of these compounds shows no toxicity over kidney, lung or liver.
These new compounds, in addition to showing marked efficacy in inhibiting proinflammatory cytokine production or signalling (a strategy that has proved to be the most effective in treating inflammation) also allow oral administration, unlike recent anti-inflammatory protein-based biological therapies.
Furthermore, this new generation of inhibitors of TNF-α production have very few side effects, in contrast to the majority of drugs currently available on the market for the treatment of inflammatory disorders, such as steroidal anti-inflammatory agents (hormones), nonsteroidal anti-inflammatory agents (NSAIDs) and humanized anti-TNF-alpha antibodies.
Estado de protección
Spanish patents P201331143 and P201430411, granted in December and October 2015, respectively.International patent application PCT/ES2014/070603.
Innovation Support Unit
Foundation for Biomedical Research of La Paz University Hospital - FIBHULP-IdiPAZ
Edificio IdiPAZ, Planta Baja
Paseo de la Castellana, 261
Tfno: 91 207 12 34
- Health technology:
- Biotecnología y Diagnóstico Molecular (proteómica, genómica, etc...)