Uso de Inductores de HO-1 y agonistas DOR o CB2 en dolor inflamatario

Desarrollado por: Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau)

Descripción

The present invention relates to a combination comprising an heme oxygenase 1 inducer and a cannabinoid 2 receptor agonist or a selective δ-opioid receptor agonist for use in the prevention and/or treatment of inflammatory pain.

HO-1 inducers, DOR and CB2R agonists have shown antinociceptive effect when used individually in the treatment of inflammatory pain. Although literature suggests antagonic effects of theses agents in neuropathic pain induced by peripheranl nerve injury, the inventor has unexpectedly found that administration of an HO-1 inducer enhances the antinociceptive effects of DOR and CB2R agonists in the treatment of inflammatory pain, i.e. a synergistic effect is obtained by the combination of a HO-1 inducer and a DOR or CB2R agonist, providing thus a new potential strategy for management of inflammatory pain.

Aplicaciones

New therapies for inflammatory pain.

Estado de protección

Euopean patent EP14183542.1 filed.

Cooperación que se desea

Co-development and license agreement

Responsable: Miriam Ors

Contacto (Tel./mail): mors(ELIMINAR)@santpau.cat    / 93 553 78 69

Estado:
En busca de codesarrolladores, En desarrollo
Tecnología sanitaria:
Medicamentos - Farma