Compounds related to 3-alkylamine-1H-indolyl acrylate and their use for the treatment of neurodegenerative diseases

Desarrollado por: IIS del Hospital Universitario de La Princesa



The design of this family of compounds was based on common pathological pathways described for different neurodegenerative diseases. For its design, we have used computational tools and predictors to avoid toxicological problems. As result, we have obtained a small molecule that has demonstrated to be moderate Nrf2 inducer, potent scavenger, antiinflammatory and neuroprotectant in several oxidative stress models, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and brain ischemic injury in vitro models.


This family of products has been protected as potential treatments for neurodegenerative diseases including all mayor diseases as: Alzheimer’s disease, Parkinson’s disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis and ictus. The target of the named compounds is oxidative stress and the Nrf2-Keap1 antioxidant and anti-inflammatory pathway, thus, their indication can be extended for different inflammatory diseases as chronic obstructive pulmonary disease, for example.

Estado de protección

PCT international application. 

Cooperación que se desea

Our interest of collaboration with pharmaceutical industry is to further develop this family of compounds. First, to perform the in vivo proof of concept of the lead compound and, second to optimize the activities to generate a drug candidate. We also are looking for biopharmaceutical companies interested in licensing the compounds or collaborating to apply for funding to the European Commision. Thus, we are open to make collaboration with companies interested in granting our project. 
En busca de codesarrolladores, En desarrollo, Transferible
Tecnología sanitaria:
Medicamentos - Farma