Compounds related to 3-alkylamine-1H-indolyl acrylate and their use for the treatment of neurodegenerative diseases
Desarrollado por: IIS del Hospital Universitario de La Princesa
The design of this family of compounds was based on common pathological pathways described for different neurodegenerative diseases. For its design, we have used computational tools and predictors to avoid toxicological problems. As result, we have obtained a small molecule that has demonstrated to be moderate Nrf2 inducer, potent scavenger, antiinflammatory and neuroprotectant in several oxidative stress models, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and brain ischemic injury in vitro models.
This family of products has been protected as potential treatments for neurodegenerative diseases including all mayor diseases as: Alzheimer’s disease, Parkinson’s disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis and ictus. The target of the named compounds is oxidative stress and the Nrf2-Keap1 antioxidant and anti-inflammatory pathway, thus, their indication can be extended for different inflammatory diseases as chronic obstructive pulmonary disease, for example.
Estado de protección
Cooperación que se desea
- En busca de codesarrolladores, En desarrollo, Transferible
- Tecnología sanitaria:
- Medicamentos - Farma